Endocrine Abstracts

Objective: Primary hyperparathyroidism (PHPT) is a clinical condition characterized by hypercalcemia-specific symptoms and signs caused by excessive secretion of parathormone. After the evaluation of blood calcium measurements within routine tests, the frequency of hyperparathyroidism increased and there is a marked decrease in the frequency of classical symptoms and signs. Recently, most PHPT cases are detected in the asymptomatic period, and which of these asymptomatic patie...

Background: Fine needle aspiration biopsy (FNAB) and Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) have proven to be the most valuable diagnostic procedure for preoperative discrimination of benign and malignant thyroid nodules. Thyroid surgery may cause regional scarring and some degree of fibrotic process which may result in problems when collecting FNAB samples and evaluating the cellular abnormalities. In this study, we aimed to determine whether the Bethesd...

Background: Immune checkpoint inhibitors, including anti-programmed cell death-1 (PD-1) antibodies, have become promising treatments for a variety of advanced malignancies. Nivolumab, an anti–PD-1 monoclonal Ab, is an effective treatment of unresectable metastatic melanoma, non–small cell lung cancer, renal cell carcinoma, head and neck cancer, Hodgkin lymphoma, and gastric cancer. These medicines can cause immune-related adverse events (irAEs), including endocrino...

Atypical tumors were identified in 15% of pituitary adenomas, and they tended to be aggressive, invasive macroadenomas. WHO classification of atypical pituitary adenomas include; Ki-67 proliferative index >3%, excessive p53 immunoreactivity, and ≥ 2 mitotic figures per 10 high-powered fields. Pituitary carcinomas are extremely rare tumors with cerebrospinal or extracranial metastasis.Case: A 31 years old man with symptoms of stuffy nose and sno...

Introduction: Fine needle aspiration cytology (FNAC) has been widely accepted the most accurate, safe and cost-effective method for evaluation of the thyroid nodules. The most challenging category in the FNAC is atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS). Bethesda System (BS) recommends repeat FNAC in that category due to their low risk of malignancy. In our study, we aimed to investigate the malignancy rate of thyroid n...

Introduction: Our objective for the current review was to inquire the thyroid cancer frequency rate within the patients who have had total thyroidectomy procedure for definitive Graves’ disease treatment and to evaluate the contribution of the presence of nodules to malignity rates.Materials and methods: The present study was conducted by scanning the data of 214 patients who were applied total thyroidectomy for permanent Graves disease treatment, r...

Introduction: In this study, we aimed to compare GH values obtained in oral glucose tolerance test (OGTT) and intravenous glucose tolerance test (IVGTT) in healthy individuals.Material and methods: Data of 18 healthy volunteers were analysed (10 male and 8 female). Firstly all subjects were evaluated with 75 g oral glucose tolerance test. In another day, intravenous glucose tolerance test was performed. Serum glucose, insulin and GH levels obtained durin...

Introduction: Follicular variant papillary thyroid carcinoma (FVPTC) is the most common variant of papillary thyroid carcinoma (PTC) after classical PTC (CPTC). In this study, we aimed to compare functional status, ultrasonographical features, cytological results and histopathological characteristics of patients with CPTC and FVPTC.Methods: Patients diagnosed with CPTC and FVPTC in our clinic were reviewed retrospectively. Data of preoperative thyroid fu...

Introduction: Aortic elastic properties and aortic stiffness are important determinants of increased cardiovascular morbidity and mortality in different diseases. We aimed to investigate the aortic function and to evaluate the relationship between aortic stiffness and systolic and diastolic functions of the left ventricle in patients with Cushing’s disease (CD).Material and method: Fourteen women and one man with newly diagnosed CD, and 17 control c...

Objective: Thyroid diseases are reported to be in 22–70% of primary hyperparathyroidism (PHPT) patients in different studies. Thyroid pathology is detected during neck exploration in some of these patients. In this study we aimed to investigate thyroid pathology in patients operated for PHPT in our clinic.Method: About 32 PHPT patients were included in the study. Patients were evaluated with thyroid function tests, antithyroglobulin antibody, antith...